Description

5-(Thien-2-Yl)-7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride group. This compound matters for its critical role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers developing new therapeutic agents, especially in the areas of kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing complex heterocyclic compounds with potential biological activity.
• Kinase Inhibitor Development: A key building block for creating novel pyrazolopyrimidine-based compounds targeting various kinase pathways.
• Chemical Biology Probes: Employed in the synthesis of specialized molecules used to study biological processes and identify new drug targets.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science: Can be utilized in the synthesis of specialized organic materials and ligands for catalysis.

Basic Information

Product Name	5-(Thien-2-Yl)-7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride
CAS No.	524036-13-3
Molecular Formula	C12H5ClF3N3OS
Molecular Weight	347.70 g/mol
Synonyms	5-(Thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; 5-(2-Thienyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride; Pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride, 5-(2-thienyl)-7-(trifluoromethyl)-; 524036-13-3; 5-(Thien-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 5-(Thien-2-Yl)-7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.