Description

Benzoyl Chloride, 5-Amino-2-Fluoro- (9Ci) CAS NO 518057-71-1 is a specialized aromatic compound featuring both an amino and a fluorine substituent on the benzoyl chloride core. This unique bifunctional structure makes it a highly valuable pharmaceutical intermediate and organic synthesis building block. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex molecules where precise halogen and amine reactivity is required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic components used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce reactive benzoyl chloride and aniline functionalities into polymer chains for specialty resins and high-performance materials.
• Peptide Chemistry & Bioconjugation: Utilized for acylating amino groups or as a linker in the preparation of peptide derivatives and antibody-drug conjugates (ADCs).
• Dye & Pigment Intermediate: Acts as a precursor in the manufacture of specialized fluorinated dyes and pigments.
• Cross-coupling Reactions: Suitable for use in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to create complex biaryl structures.
• Research & Development: Essential reagent in academic and industrial laboratories for medicinal chemistry and novel synthetic route exploration.

Basic Information

Product Name	Benzoyl Chloride, 5-Amino-2-Fluoro- (9Ci)
CAS No.	518057-71-1
Molecular Formula	C7H5ClFNO
Molecular Weight	173.57 g/mol
Synonyms	5-Amino-2-fluorobenzoyl chloride; 2-Fluoro-5-aminobenzoyl chloride; 5-Amino-2-fluorobenzoic acid chloride; (5-Amino-2-fluorophenyl)(chloro)methanone; 2-Fluoro-5-nitrobenzoyl chloride (reduction precursor); Benzoyl chloride, 5-amino-2-fluoro-; 518057-71-1
EINECS	Contact for details

Quality Control

Our Benzoyl Chloride, 5-Amino-2-Fluoro- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.