Description

8-(4-Chlorophenylthio)-2',o-Methyladenosine 3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP), a critical secondary messenger in cellular signaling pathways. This compound matters as a potent and selective activator of protein kinase A (PKA), making it an invaluable pharmacological tool for probing cAMP-dependent signaling in biological research. It is primarily needed by researchers in pharmaceutical R&D, biochemistry, and molecular biology for studying cellular processes, signal transduction mechanisms, and as a reference standard.

Application

• Biochemical Research: Used as a potent and cell-permeable activator of Protein Kinase A (PKA) to study cAMP-mediated signal transduction pathways.
• Pharmaceutical Development: Serves as a key reference standard and pharmacological tool compound in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and intracellular signaling.
• Cell Biology Studies: Employed to investigate the role of cAMP in cellular functions such as gene expression, metabolism, ion channel regulation, and cell differentiation.
• Enzyme Assays: Utilized in in vitro enzymatic assays to study the kinetics and inhibition of phosphodiesterases (PDEs) and adenylate cyclase.
• Neuroscience Research: Applied in studies of neuronal plasticity, neurotransmitter release, and long-term potentiation (LTP) where cAMP signaling is involved.
• Cardiovascular Research: Used to model and understand cAMP's effects on heart muscle contraction, vascular tone, and smooth muscle relaxation.

Basic Information

Product Name	8-(4-Chlorophenylthio)-2',o-Methyladenosine 3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	510774-50-2
Molecular Formula	C18H17ClN5O6PSNa
Molecular Weight	527.84 g/mol
Synonyms	8-(p-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt; 8-CPT-2'-O-Me-cAMP sodium salt; 8-(4-Chlorophenylthio)-2'-O-methyl-cAMP sodium salt; 2'-O-Methyl-8-(4-chlorophenylthio)adenosine-3',5'-cyclic monophosphate sodium salt; 8-CPT-2'-O-Me-cAMP, Na salt; Protein Kinase A Activator (8-CPT-2'-O-Me-cAMP); 8-(4-Chlorophenylthio)-2'-O-methyl-cyclic AMP sodium salt
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing batch-specific results from HPLC, NMR, and mass spectrometry are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Confirmed in cell-based assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.