Description

Px-866 CAS NO 502632-66-8 is a potent and selective small-molecule inhibitor of phosphatidylinositol 3-kinase (PI3K), specifically targeting the p110α isoform. This compound is a critical research tool for investigating the PI3K/AKT/mTOR signaling pathway, which is a central regulator of cell growth, proliferation, and survival and is frequently dysregulated in cancer. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on oncology, metabolic disorders, and signal transduction studies.

Application

• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies targeting PI3K-driven cancers.
• Biochemical Assay Development: Serves as a key inhibitor in high-throughput screening (HTS) and enzymatic assays to study PI3K activity and inhibition kinetics.
• Cell Signaling Studies: A vital tool for elucidating the role of the PI3K pathway in cell proliferation, apoptosis, and metabolism in various cell lines.
• Drug Discovery & Development: Employed in lead optimization, structure-activity relationship (SAR) studies, and as a comparator for novel PI3K inhibitor candidates.
• Academic & Institutional Research: Facilitates fundamental research in molecular biology, pharmacology, and cancer biology.
• Biomarker Research: Used in studies to identify and validate predictive biomarkers for PI3K inhibitor therapy response.

Basic Information

Product Name	Px-866
CAS No.	502632-66-8
Molecular Formula	C₂₀H₂₀N₄O₄
Molecular Weight	380.40 g/mol
Synonyms	Px-866; PX866; PX 866; Sonolisib; Wortmannin analog; PI3K inhibitor PX-866; (1E,4E,6R,9S,11E,13S,15R)-6-Acetoxy-9,13-dihydroxy-15-[(2S,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentadeca-1,4,11-trien-8-one; 4H-Furo[3,2-c]pyran-4-one, 5-(hydroxymethyl)-2-[(1E)-1-(hydroxyimino)-3-phenylpropyl]-
EINECS	Contact for details

Quality Control

Our Px-866 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and potency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Biological Activity (IC50)	Reported value provided (PI3K p110α)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.