Description

1-[4-(4-Aminofuro[2,3-D]Pyrimidin-5-Yl)Phenyl]-3-[2-Fluoro-5-(Trifluoromethyl)Phenyl]Urea is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the research and development of novel therapeutic agents, particularly kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting oncology and other disease areas. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical synthesis pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially protein kinase inhibitors.
• Oncology Research: Serves as a core scaffold for developing novel anti-cancer compounds in preclinical and clinical research stages.
• Biochemical Tool Compound: Used in high-throughput screening (HTS) and assay development to study enzyme inhibition and cellular signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and structure-activity relationship (SAR) studies.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary molecules for client-specific drug discovery programs.

Basic Information

Product Name	1-[4-(4-Aminofuro[2,3-D]Pyrimidin-5-Yl)Phenyl]-3-[2-Fluoro-5-(Trifluoromethyl)Phenyl]Urea
CAS No.	501693-48-7
Molecular Formula	C20H13F4N5O2
Molecular Weight	431.34 g/mol
Synonyms	5-[4-[[[2-Fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]furo[2,3-d]pyrimidin-4-amine; N-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea; 1-(4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea; BIRB 796 Derivative Intermediate; p38 MAP Kinase Inhibitor Intermediate; CAS 501693-48-7.
EINECS	Contact for details

Quality Control

Our 1-[4-(4-Aminofuro[2,3-D]Pyrimidin-5-Yl)Phenyl]-3-[2-Fluoro-5-(Trifluoromethyl)Phenyl]Urea is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material suitable for use under GMP conditions for non-clinical studies upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.