Description

2-Fluoro-6-Methoxybenzoyl Chlorid is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 2-fluoro-6-methoxybenzoyl moiety, a key structural feature for modulating the biological activity and physicochemical properties of target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anticancer compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and methoxy groups enhance metabolic stability and target binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require specific aromatic fluorinated components.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic and R&D Laboratories: Used in medicinal chemistry programs and methodological research to explore new synthetic routes and compound libraries.

Basic Information

Product Name	2-Fluoro-6-Methoxybenzoyl Chlorid
CAS No.	500912-12-9
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-Fluoro-6-methoxybenzoyl chloride; 2-Fluoro-6-methoxybenzoic acid chloride; 2-Fluoro-6-methoxybenzoylchloride; 2-Fluoro-6-methoxy-benzoic acid chloride; 2-Fluoro-6-methoxybenzenecarbonyl chloride; 2-Fluoro-6-methoxybenzoylchlorid; 6-Methoxy-2-fluorobenzoyl chloride; 500912-12-9 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Methoxybenzoyl Chlorid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C (refrigerated) for long-term stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.