Description

Diethyl [2-Oxo-3-(Triphenylphosphoranylidene)Propyl]Phosphonate is a specialized organophosphorus reagent, widely recognized as a key Horner-Wadsworth-Emmons (HWE) reagent for the synthesis of α,β-unsaturated carbonyl compounds. Its primary value lies in its ability to facilitate highly stereoselective olefination reactions under mild conditions, offering superior control over the geometry of the resulting alkene compared to traditional Wittig reagents. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require efficient and reliable methods for constructing complex molecular frameworks.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for constructing α,β-unsaturated esters, ketones, and amides, which are key scaffolds in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of complex molecules for novel pesticides, herbicides, and plant growth regulators.
• Fine Chemical & Specialty Material Production: Enables the synthesis of advanced intermediates for dyes, fragrances, and liquid crystals.
• Academic & Industrial R&D: A staple reagent in organic synthesis laboratories for method development and the construction of complex natural products and novel organic compounds.
• Stereoselective Alkene Synthesis: Specifically employed for the preparation of (E)-selective α,β-unsaturated carbonyl systems with high isomeric purity.

Basic Information

Product Name	Diethyl [2-Oxo-3-(Triphenylphosphoranylidene)Propyl]Phosphonate
CAS No.	59925-00-7
Molecular Formula	C25H28O4P2
Molecular Weight	454.43 g/mol
Synonyms	Diethyl (2-oxo-3-(triphenylphosphoranylidene)propyl)phosphonate; (Carbethoxymethylene)triphenylphosphorane Diethyl Phosphonate Analog; Diethyl (3-(Triphenylphosphoranylidene)-2-oxopropyl)phosphonate; HWE Reagent for α,β-Unsaturated Esters; Horner-Wadsworth-Emmons Reagent; (Ethoxycarbonylmethylene)triphenylphosphorane Phosphonate Ester; Diethyl (2-Oxo-3-(triphenyl-λ5-phosphanylidene)propyl)phosphonate
EINECS	Contact for details

Quality Control

Our Diethyl [2-Oxo-3-(Triphenylphosphoranylidene)Propyl]Phosphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.