Description

2-Amino-2-Methylpropanoyl Chloride Hydrochloride is a versatile and highly reactive chemical intermediate, primarily valued for its role in the synthesis of more complex organic molecules. Its bifunctional nature, containing both an acid chloride and a protected amino group, makes it a critical building block for introducing the 2-aminoisobutyric acid (Aib) moiety, which is known to induce specific conformational changes in peptides. This compound is essential for research and production in the pharmaceutical and agrochemical sectors, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of peptidomimetics and active pharmaceutical ingredients (APIs), particularly those incorporating the 2-aminoisobutyric acid residue to enhance metabolic stability.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to introduce constrained, helix-inducing Aib units into peptide chains for structure-activity relationship (SAR) studies.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and plant growth regulators with tailored biological activity.
• Material Science: Employed in the synthesis of specialized polymers and dendrimers with unique thermal and mechanical properties.
• Bioconjugation: Useful for modifying biomolecules, proteins, or surfaces due to its reactive acid chloride group, facilitating the creation of diagnostic agents or drug delivery systems.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical manufacturers and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Amino-2-Methylpropanoyl Chloride Hydrochloride
CAS No.	59660-95-6
Molecular Formula	C4H9Cl2NO
Molecular Weight	158.03 g/mol
Synonyms	2-Amino-2-methylpropionyl chloride hydrochloride; 2-Aminoisobutyryl chloride hydrochloride; Aib-Cl·HCl; 2-Methylalanine chloride hydrochloride; 2-Amino-2-methylpropanoyl chloride HCl; 2-Amino-2-methylpropanoic acid chloride hydrochloride; (Aminoisobutyryl)chloride hydrochloride; 2-Aminoisobutyric acid chloride hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-2-Methylpropanoyl Chloride Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.