Description

1H-Indole-3-Carbonyl Chloride is a versatile and highly reactive chemical building block, essential for the synthesis of complex organic molecules. Its core value lies in its ability to efficiently introduce the indole-3-carbonyl moiety, a key structural feature in numerous biologically active compounds. This product is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of tryptophan-derived drug candidates, receptor modulators, and enzyme inhibitors.
• Agrochemical Synthesis: Building block for developing novel plant growth regulators, fungicides, and herbicides with indole-based structures.
• Peptide Mimetics & Bioconjugation: Used to incorporate indole scaffolds into peptide chains or for labeling biomolecules.
• Material Science Research: Employed in the creation of organic semiconductors, fluorescent dyes, and photoresponsive polymers.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in organic synthesis and medicinal chemistry research.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	1H-Indole-3-Carbonyl Chloride
CAS No.	59496-25-2
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	Indole-3-carbonyl chloride; 3-Indolecarbonyl chloride; 1H-Indole-3-carboxylic acid chloride; Indol-3-carbonyl chloride; 3-Carboxyindole acid chloride; Indole-3-Carboxychloride; 59496-25-2; Indolyl-3-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.