Description

O(4)-Ethylthymidine is a chemically modified nucleoside derivative, specifically an ethylated analog of thymidine. This compound is of significant value as a versatile building block and intermediate in synthetic organic chemistry and pharmaceutical research. It is primarily needed by researchers and manufacturers in the fields of nucleoside chemistry, antiviral drug development, and molecular biology, where it serves as a key precursor for creating novel therapeutic agents and probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a modified substrate to study enzyme mechanisms, particularly those involving DNA polymerases and kinases.
• Pro-drug Development: Serves as a building block for designing lipophilic pro-drugs to enhance cellular uptake and bioavailability of active nucleosides.
• Antisense Oligonucleotide Synthesis: Employed in the creation of modified oligonucleotides for research into gene silencing and therapeutic applications.
• Chemical Biology Tool: Utilized for labeling and probing nucleic acid structures and interactions due to its modified base.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	O(4)-Ethylthymidine
CAS No.	59495-22-6
Molecular Formula	C12H18N2O5
Molecular Weight	270.28 g/mol
Synonyms	4-Ethoxythymidine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-4-ethoxypyrimidin-2(1H)-one; Thymidine, 4-ethoxy-; 4-Ethoxy-2'-deoxythymidine; 4-O-Ethylthymidine; 5-Methyl-4-ethoxy-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our O(4)-Ethylthymidine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.