Description

3-Thiophenecarbonyl Chloride, 4-Chloro- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. Its core value lies in its ability to introduce the 4-chlorothiophene-3-carbonyl moiety, a key structural motif in the development of novel active compounds. This intermediate is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiophene scaffold contributes to biological activity.
• Material Science Research: Serves as a precursor for functionalized monomers in the development of conductive polymers and organic electronic materials.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal catalysis and organocatalysts.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	3-Thiophenecarbonyl Chloride, 4-Chloro- (9Ci)
CAS No.	59337-80-3
Molecular Formula	C5H2Cl2OS
Molecular Weight	181.04 g/mol
Synonyms	4-Chlorothiophene-3-carbonyl chloride; 4-Chloro-3-thiophenecarbonyl chloride; 4-Chloro-3-thenoyl chloride; 4-Chloro-thiophene-3-carbonyl chloride; 3-Thenoyl chloride, 4-chloro-; 4-Chloro-3-thiophenoyl chloride; 4-Chloro-3-thienylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Thiophenecarbonyl Chloride, 4-Chloro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; ensure the container is kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain purity. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.