Description

Adenosine-5'-o-(1-Thiodiphosphate), Rp-Isomer Sodium Salt is a high-purity, stereochemically defined nucleotide analog where one of the non-bridging oxygen atoms in the diphosphate moiety is replaced by sulfur in the Rp configuration. This compound is a critical tool in biochemical and pharmacological research, serving as a hydrolysis-resistant agonist or antagonist for probing the structure and function of ATP-dependent enzymes and receptors. It is essential for researchers in molecular biology, enzymology, and drug discovery who require precise, stable ligands to study signaling pathways, kinase activity, and nucleotide-binding proteins.

Application

• Enzyme Mechanism Studies: Used as a non-hydrolyzable ATP analog to investigate the catalytic mechanisms of kinases, ATPases, and other phosphotransferases.
• P2 Receptor Research: Acts as a selective agonist/antagonist for characterizing purinergic P2Y receptor subtypes and their signaling cascades.
• Structural Biology: Employed in X-ray crystallography and NMR studies to determine the three-dimensional structure of nucleotide-binding protein complexes.
• High-Throughput Screening (HTS): Serves as a key substrate or inhibitor in assay development for drug discovery targeting ATP-binding sites.
• Signal Transduction Research: Utilized to modulate and study intracellular signaling pathways involving cyclic nucleotides and energy metabolism.
• Biochemical Assay Standard: Provides a stable reference standard for calibrating assays measuring nucleotide-dependent enzymatic activity.

Basic Information

Product Name	Adenosine-5'-o-(1-Thiodiphosphate), Rp-Isomer Sodium Salt
CAS No.	59331-71-4
Molecular Formula	C10H14N5O9P2S · xNa
Molecular Weight	Contact for details
Synonyms	ADP-α-S, Rp isomer; Adenosine 5'-(α-thiodiphosphate), Rp isomer; Rp-ADP-α-S sodium salt; Adenosine-5'-diphosphorothioate (Rp isomer); ATPαS Rp isomer (common misnomer); P1-(5'-Adenosyl)-P2-(monothiophosphate) Rp-isomer; 5'-Adenylyl (α-thiodiphosphate) Rp-isomer
EINECS	Contact for details

Quality Control

Our Adenosine-5'-o-(1-Thiodiphosphate), Rp-Isomer Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and stereochemical identity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the assay, impurity profile, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Isomeric Purity (Rp-isomer)	≥ 98%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.