Description

N4-Desmethyl Wyosine CAS NO 59327-60-5 is a high-purity nucleoside derivative and a key intermediate in the synthesis of modified tRNA bases and related biochemical research compounds. Its precise structure makes it an essential building block for investigating RNA modification pathways and developing novel therapeutic agents. This product is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on nucleic acid chemistry and molecular biology.

Application

• Biochemical Research: Critical intermediate for the study of wyosine derivatives and hypermodified nucleosides in tRNA.
• Pharmaceutical R&D: Serves as a building block in the synthesis of potential antiviral and anticancer nucleoside analogs.
• Enzymology Studies: Used as a substrate or inhibitor to study tRNA-modifying enzymes, such as methyltransferases.
• Standards and References: Acts as a certified reference standard (CRS) for analytical method development and quality control in nucleic acid research.
• Probe Development: Utilized in creating labeled probes for investigating RNA structure, function, and localization.
• Academic Research: Fundamental tool in universities and labs exploring genetic code expansion and translational regulation.

Basic Information

Product Name	N4-Desmethyl Wyosine
CAS No.	59327-60-5
Molecular Formula	C16H19N5O5
Molecular Weight	361.36 g/mol
Synonyms	1-Methyl-4-demethylwyosine; 4-Demethylwyosine; 1-Methyl-4-demethylwyosine; N(4)-Demethylwyosine; 1-Methyl-4-demethylwyosine; 4-Demethyl-1-methylwyosine; Wyosine, N4-desmethyl-; 1-Methyl-4-demethyl-α-amino-2,4-dihydro-4-oxo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our N4-Desmethyl Wyosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for research-grade biochemicals to support your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.