Description

Diflucortolone Valerate CAS NO 59198-70-8 is a potent synthetic corticosteroid ester, widely recognized for its significant anti-inflammatory and antipruritic properties. This high-purity active pharmaceutical ingredient (API) is critical for formulators requiring reliable and consistent efficacy in topical dermatological preparations. It is primarily sought by pharmaceutical manufacturers and R&D laboratories specializing in advanced topical therapies for inflammatory skin conditions.

Application

• Primary Use in Topical Corticosteroids: As the key active ingredient in creams, ointments, and lotions for treating severe inflammatory dermatoses such as psoriasis, eczema, and contact dermatitis.
• Dermatological R&D: Serves as a reference standard and a critical component in the development of new topical formulations with enhanced delivery and potency.
• Veterinary Pharmaceuticals: Used in topical preparations for managing inflammatory skin conditions in animals.
• Compounding Pharmacy: Employed by specialized pharmacies for preparing customized topical medications where commercial formulations are unsuitable.
• Analytical and Quality Control: Utilized as a certified reference material (CRM) for HPLC, LC-MS, and other analytical methods to ensure product quality and regulatory compliance.

Basic Information

Product Name	Diflucortolone Valerate
CAS No.	59198-70-8
Molecular Formula	C₂₇H₃₆F₂O₅
Molecular Weight	478.57 g/mol
Synonyms	Diflucortolone 21-Valerate; 6α,9α-Difluoro-16α-methylprednisolone 17-valerate; NSC-121055; Nerisone (trade name); Flucort Valerate; Diflucortolone Pivalate (related compound); (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-valerate
EINECS	261-645-2

Quality Control

Our Diflucortolone Valerate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to support your regulatory and formulation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.