Description

3-Fluoro-4-Methylbenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the 3-fluoro-4-methylbenzoyl moiety into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), advanced intermediates, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the manufacturing of herbicides and fungicides, where the fluorine and methyl substituents can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Acts as a monomer for creating specialized polymers and small molecules used in display technologies and organic electronics.
• Peptide Coupling Reagent: Facilitates amide bond formation in peptide synthesis and other coupling reactions due to its high acylating activity.
• Dye & Pigment Manufacturing: Intermediate for producing complex aromatic dyes and high-performance pigments.
• Polymer Chemistry: Used to synthesize polyamides, polyesters, and other polymers with specific thermal and chemical resistance properties.
• Custom Synthesis & Contract Research: Essential for research organizations and CDMOs (Contract Development and Manufacturing Organizations) developing proprietary compounds.

Basic Information

Product Name	3-Fluoro-4-Methylbenzoyl Chloride
CAS No.	59189-97-8
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	4-Methyl-3-fluorobenzoyl chloride; 3-Fluoro-p-toluoyl chloride; 3-Fluoro-4-methylbenzoic acid chloride; 3-Fluoro-4-methyl-benzoyl chloride; 59189-97-8; 4-Methyl-3-fluorobenzoic acid chloride; 3-Fluoro-4-methylbenzoylchloride; Benzoic acid, 3-fluoro-4-methyl-, chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methylbenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.