Description

2-(2-(1,3-Dioxoisoindolin-2-Yl)Acetamido)Acetyl Chloride is a high-purity, reactive chemical intermediate featuring a phthalimide-protected amino acid chloride functionality. This compound is critical for enabling efficient, high-yield peptide coupling and amide bond formation in complex synthetic sequences. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and advanced organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of peptide-based drugs and complex organic molecules with potential therapeutic activity.
• Peptide Synthesis: Serves as an activated acylating agent for the controlled introduction of specific amino acid residues in solid-phase and solution-phase peptide synthesis.
• Protecting Group Chemistry: The phthalimide (Pht) group acts as a robust amine protector, with the chloride handle allowing for selective deprotection and further functionalization in multi-step syntheses.
• Bioconjugation: Used in the modification of biomolecules, such as proteins or antibodies, for creating targeted drug conjugates or diagnostic probes.
• Agrochemical Research: Employed in the research and development of novel pesticides and herbicides that require specific amide linkages.
• Material Science: A precursor for synthesizing specialized polymers and dendrimers with tailored properties for advanced material applications.

Basic Information

Product Name	2-(2-(1,3-Dioxoisoindolin-2-Yl)Acetamido)Acetyl Chloride
CAS No.	59180-28-8
Molecular Formula	C₁₂H₉ClN₂O₄
Molecular Weight	280.66 g/mol
Synonyms	N-(Chloroacetyl)-N-(1,3-dioxoisoindolin-2-yl)glycine; 2-[(2-Chloroacetyl)amino]-N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide; N-(1,3-Dioxoisoindolin-2-yl)glycyl Chloride; Phthalimidoacetic Acid Chloride Derivative; Pht-Gly-Cl; N-(Chloroacetyl)phthalamidoacetic Acid; Glycine, N-(chloroacetyl)-N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-; 59180-28-8
EINECS	Contact for details

Quality Control

Our 2-(2-(1,3-Dioxoisoindolin-2-Yl)Acetamido)Acetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is analyzed using advanced techniques including HPLC, NMR, and FT-IR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.