Description

1-Acetylisonipecotoyl Chloride is a versatile and reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 1-acetylisonipecotoyl moiety, a privileged scaffold in medicinal chemistry. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex molecules, particularly those containing the isonipecotic acid or tropane alkaloid-derived pharmacophores.
• API Synthesis: Used in the research and development of new Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and analgesic drug candidates.
• Peptide Mimetics & Prodrug Development: Facilitates the creation of peptide analogs and prodrug forms by acting as an acylating agent for amines and alcohols.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Ligand & Catalyst Development: Useful for modifying ligands and creating novel organocatalysts or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Acetylisonipecotoyl Chloride
CAS No.	59084-16-1
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64 g/mol
Synonyms	1-Acetyl-4-piperidinecarbonyl chloride; 4-(Chlorocarbonyl)-1-acetylpiperidine; 1-Acetylisonipecotic acid chloride; 1-Acetylpiperidine-4-carbonyl chloride; Isonipecotoyl chloride, 1-acetyl-; 4-Piperidinecarbonyl chloride, 1-acetyl-
EINECS	Contact for details

Quality Control

Our 1-Acetylisonipecotoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.