Description

Sinefungin is a potent nucleoside antibiotic and a competitive inhibitor of S-adenosylmethionine-dependent methyltransferases. This unique mechanism of action makes it a critical biochemical tool for epigenetic research and the study of viral replication. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery and fundamental enzymology studies. Sinefungin CAS NO 58944-73-3 is supplied as a high-purity biochemical reagent to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: As a key inhibitor for studying S-adenosylmethionine (SAM)-dependent methyltransferases in epigenetic regulation.
• Antiviral Studies: Investigation of antiviral activity, particularly against viruses like vaccinia and other poxviruses, due to its inhibition of mRNA cap methylation.
• Enzymology: Used as a standard or probe in enzymatic assays to characterize methyltransferase activity and kinetics.
• Pharmaceutical R&D: Serves as a lead compound or reference standard in the discovery and development of novel methyltransferase-targeting therapeutics.
• Cell Biology: Research into the role of protein and nucleic acid methylation in cellular processes and signaling pathways.

Basic Information

Product Name	Sinefungin
CAS No.	58944-73-3
Molecular Formula	C15H23N7O5
Molecular Weight	381.39 g/mol
Synonyms	A9145; Antibiotic A9145; NSC 329046; Sinefungine; 5'-Deoxy-5'-[3-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]propylamino]-5'-oxoadenosine
EINECS	Contact for details

Quality Control

Our Sinefungin is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research-grade biochemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.