Description

Icrf 192 is a potent and selective inhibitor of the DNA topoisomerase II enzyme, functioning as a catalytic inhibitor. This compound is a critical research tool for studying cell cycle dynamics, DNA replication, and the mechanisms of chemotherapeutic agents. It is primarily utilized by researchers in pharmaceutical R&D, academic biochemistry, and oncology research to investigate DNA damage response pathways and evaluate novel cancer treatment strategies.

Application

• Biochemical Research: Used as a specific catalytic inhibitor of topoisomerase II to study its role in DNA replication, transcription, and chromosome segregation.
• Cancer Research: Employed in in vitro and cell-based assays to investigate mechanisms of cell cycle arrest, apoptosis, and to differentiate between topoisomerase II poisons and catalytic inhibitors.
• Pharmaceutical Development: Serves as a reference standard and pharmacological tool in the discovery and validation of new anticancer therapeutics targeting topoisomerase II.
• Molecular Biology Studies: Applied to probe DNA topology changes and understand the cellular response to DNA damage without causing double-strand breaks associated with classic topoisomerase II poisons.

Basic Information

Product Name	Icrf 192
CAS No.	58893-33-7
Molecular Formula	C20H22N4O2
Molecular Weight	350.42 g/mol
Synonyms	ICRF-192; ICRF 192; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; NSC 169780; Dexrazoxane derivative; Topoisomerase II Catalytic Inhibitor; Bisdioxopiperazine
EINECS	Contact for details

Quality Control

Our Icrf 192 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.