Description

1H-Indole-2-Carbonyl Chloride is a versatile and highly reactive organic intermediate, essential for constructing complex indole-based molecular frameworks. Its primary value lies in its role as a key acylating agent, enabling the efficient synthesis of amides, esters, and other functionalized indole derivatives. This compound is critically needed by research chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, serotonin receptor modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that incorporate the indole scaffold for enhanced biological activity.
• Peptide Mimetics & Conjugation: Facilitates the introduction of the indole-2-carbonyl group into peptides and proteins for creating targeted bioconjugates and mimetics.
• Material Science Research: Serves as a precursor for functionalized polymers and organic electronic materials that require specific indole-based monomers.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and medicinal chemistry research projects.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.

Basic Information

Product Name	1H-Indole-2-Carbonyl Chloride
CAS No.	58881-45-1
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	Indole-2-carbonyl chloride; 2-Indolecarbonyl chloride; 1H-Indole-2-carboxylic acid chloride; 2-Carboxyindole chloride; Indol-2-carbonylchlorid; 58881-45-1; 1H-Indole-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole-2-Carbonyl Chloride is manufactured and tested under strict quality management protocols to ensure high purity and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.