Description

4-(Trifluoroacetyl)Benzoic Acid Chloride is a high-value, reactive aromatic acid chloride derivative featuring a trifluoroacetyl functional group. This compound is a critical building block in advanced organic synthesis, prized for its ability to introduce both a benzoic acid chloride moiety and a highly electron-withdrawing trifluoroacetyl group in a single step. It is essential for pharmaceutical intermediates, agrochemicals, and the development of specialty materials, particularly where enhanced lipophilicity and metabolic stability are required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring trifluoromethylated aromatic systems.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoroacetyl group improves biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for electron-transport materials and ligands in electronic display technologies.
• Polymer Modification: Employed to introduce reactive sites and fluorinated groups into polymer chains for specialty coatings and high-performance resins.
• Peptide & Protein Chemistry: Useful as a coupling agent or for modifying amino acid side chains in biochemical research.
• Complex Ligand Synthesis: Facilitates the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(Trifluoroacetyl)Benzoic Acid Chloride
CAS No.	58808-60-9
Molecular Formula	C9H4ClF3O2
Molecular Weight	236.57 g/mol
Synonyms	4-(Trifluoroacetyl)benzoyl chloride; p-(Trifluoroacetyl)benzoyl chloride; 4-(Trifluoroacetyl)benzoic acid chloride; α,α,α-Trifluoro-4-(chlorocarbonyl)acetophenone; 4-(2,2,2-Trifluoroacetyl)benzoyl chloride; Benzoic acid, 4-(trifluoroacetyl)-, chloride; 4-Carboxybenzotrifluoride acid chloride
EINECS	Contact for details

Quality Control

Our 4-(Trifluoroacetyl)Benzoic Acid Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.