Description

2-Thiophenecarbonyl Fluoride, 5-Bromo- (9Ci) is a specialized organofluorine building block featuring a reactive carbonyl fluoride group on a brominated thiophene scaffold. This compound is valued for its dual functionality, where the bromine atom offers a versatile site for cross-coupling reactions, and the carbonyl fluoride group serves as a highly reactive electrophile for introducing the thiophene moiety into complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for incorporating the thiophene heterocycle into target molecules.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the thiophene ring system imparts specific biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, organic semiconductors, and liquid crystals due to the electronic properties of the thiophene unit.
• Cross-Coupling Reactions: The bromine substituent enables Suzuki, Stille, and other palladium-catalyzed couplings to construct complex biaryl and heteroaryl systems.
• Fluorination Agent: The carbonyl fluoride group acts as a source of fluorine or a reactive handle for amide and ester formation under mild conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.

Basic Information

Product Name	2-Thiophenecarbonyl Fluoride, 5-Bromo- (9Ci)
CAS No.	58777-70-1
Molecular Formula	C5H2BrFOS
Molecular Weight	208.03 g/mol
Synonyms	5-Bromo-2-thiophenecarbonyl fluoride; 5-Bromothiophene-2-carbonyl fluoride; 2-Thiophenecarbonyl fluoride, 5-bromo-; 5-Bromo-2-furoyl fluoride (common misnomer check); Bromothiophenoyl fluoride; 5-Bromothienoyl fluoride; 2-Carbonyl fluoride-5-bromothiophene
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonyl Fluoride, 5-Bromo- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.