Description

2-Thiophenecarbonyl Fluoride, 4-Bromo- (9Ci) is a specialized organofluorine building block featuring a reactive carbonyl fluoride group on a brominated thiophene scaffold. This compound matters for its dual functionality, offering sites for nucleophilic substitution via the bromine atom and for amide/carboxylic acid derivative formation via the acid fluoride group. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules with thiophene cores in drug discovery and development programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate heterocyclic structures.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to the thiophene moiety.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings.
• Peptide Mimetic & Bio-conjugation: The reactive acid fluoride group can be used for efficient coupling with amines to create amide bonds, useful in probe and linker synthesis.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	2-Thiophenecarbonyl Fluoride, 4-Bromo- (9Ci)
CAS No.	58777-69-8
Molecular Formula	C5H2BrFOS
Molecular Weight	208.03 g/mol
Synonyms	4-Bromo-2-thiophenecarbonyl fluoride; 4-Bromothiophene-2-carbonyl fluoride; 2-Thiophenecarbonyl fluoride, 4-bromo-; 4-Bromo-2-furoyl fluoride (common misnomer check); 4-Bromothiophene-2-carboxylic acid fluoride; Bromothiophenecarbonyl fluoride
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonyl Fluoride, 4-Bromo- (9Ci) is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.