Description

2'-Azido-D-Adenosine is a chemically modified nucleoside analog, specifically an azido-functionalized derivative of adenosine. This compound is a critical building block in chemical biology and medicinal chemistry, primarily valued for its role in bioorthogonal click chemistry applications. It is essential for researchers and manufacturers in the fields of pharmaceutical development, oligonucleotide synthesis, and proteomics who require precise tools for labeling and crosslinking biomolecules.

Application

• Click Chemistry Reagent: Acts as a key substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label or functionalize biomolecules.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite precursor for the site-specific incorporation of azide groups into DNA or RNA strands.
• Proteomics Research: Enables the study of protein-nucleic acid interactions through covalent crosslinking and affinity purification strategies.
• Antiviral Drug Development: Serves as a scaffold or intermediate in the synthesis of nucleoside analog prodrugs targeting viral polymerases.
• Bioconjugation: Facilitates the attachment of fluorophores, biotin, or other probes to nucleic acids for detection and imaging.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and other target identification studies.

Basic Information

Product Name	2'-Azido-D-Adenosine
CAS No.	58699-61-9
Molecular Formula	C10H12N8O4
Molecular Weight	308.26 g/mol
Synonyms	2'-Azido-2'-deoxyadenosine; 2'-N3-2'-dA; 9-[(2R,3R,4S,5R)-3-Azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-amine; 2'-Azidoadenosine; Adenosine, 2'-azido-2'-deoxy-; 2'-Azido-2'-deoxy-D-adenosine
EINECS	Contact for details

Quality Control

Our 2'-Azido-D-Adenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.