Description

5-Carboxymethyl-2-Thiouridine is a chemically modified nucleoside derivative, a key building block in advanced biochemical research and pharmaceutical development. Its unique structure, featuring a carboxymethyl group and a thio modification at the 2-position of the uracil base, makes it a valuable precursor for synthesizing novel oligonucleotides and exploring RNA structure-function relationships. This compound is primarily sought by research institutions and pharmaceutical companies engaged in nucleoside chemistry, antiviral drug discovery, and the development of diagnostic probes and therapeutic agents targeting genetic diseases.

Application

• Nucleoside Chemistry Research: Serves as a critical intermediate for the synthesis of modified nucleosides and nucleotides with tailored properties.
• Antiviral & Anticancer Drug Discovery: Used as a building block to create novel nucleoside analogs for screening against viral polymerases and cancer cell lines.
• Oligonucleotide Synthesis: A precursor for incorporating thio-modified bases into oligonucleotides, enhancing their stability and binding affinity.
• Biochemical Probe Development: Utilized in creating labeled probes for studying RNA-protein interactions and enzymatic mechanisms.
• Academic & Pharmaceutical R&D: Essential for fundamental research in molecular biology, structural biology, and medicinal chemistry.

Basic Information

Product Name	5-Carboxymethyl-2-Thiouridine
CAS No.	58479-77-9
Molecular Formula	C11H14N2O7S
Molecular Weight	318.30 g/mol
Synonyms	2-Thio-5-carboxymethyluridine; 5-(Carboxymethyl)-2-thiouridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(carboxymethyl)-2-sulfanylidene-1,2-dihydropyrimidin-4-one; 2-Thiouridine-5-acetic acid; 5-CMTU; 2-Thio-5-CMU; 5-Carboxymethyl-2-thiouracil riboside
EINECS	Contact for details

Quality Control

Our 5-Carboxymethyl-2-Thiouridine is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be tailored to meet specific research-grade or custom synthesis requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.