Description

5-Cyanomethyl Uridine is a modified nucleoside derivative of uridine, featuring a cyanomethyl group at the 5-position of the pyrimidine ring. This specific chemical modification makes it a valuable intermediate for the synthesis of more complex nucleoside analogs and oligonucleotides. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, development of antiviral agents, and as a building block for nucleic acid chemistry. The compound is supplied with a high level of purity to meet the stringent requirements of advanced research and production.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified monomer for the solid-phase synthesis of oligonucleotides with specific properties for research and diagnostic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related biological pathways.
• Prodrug Development: Employed in the design and creation of prodrugs to enhance the bioavailability and targeting of nucleoside analogs.
• Labeled Compound Synthesis: Acts as a precursor for the synthesis of isotopically labeled (e.g., 13C, 15N) nucleosides for use in metabolic tracing and NMR studies.
• Antisense Technology: A component in the development of antisense oligonucleotides designed to modulate gene expression for therapeutic purposes.

Basic Information

Product Name	5-Cyanomethyl Uridine
CAS No.	58479-73-5
Molecular Formula	C11H13N3O6
Molecular Weight	283.24 g/mol
Synonyms	5-(Cyanomethyl)uridine; Uridine, 5-(cyanomethyl)-; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-(cyanomethyl)pyrimidine-2,4-dione; 5-Cyanomethyl-1-β-D-ribofuranosyluracil; 5-CMU
EINECS	Contact for details

Quality Control

Every batch of 5-Cyanomethyl Uridine is produced and tested under strict quality management protocols to ensure consistency and reliability for critical research and production applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.