Description

5-Hydroxymethyl-2',3'-o-Isopropylidene-2-Thiouridine is a sophisticated nucleoside derivative, specifically a protected thiouridine analog, that serves as a critical building block in synthetic organic chemistry and pharmaceutical research. Its primary value lies in its role as a key intermediate for the synthesis of modified oligonucleotides and nucleoside-based therapeutics, enabling precise structural modifications. This compound is essential for researchers and manufacturers in the fields of antiviral drug development, antisense oligonucleotide synthesis, and advanced biochemical studies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Oligonucleotide Synthesis: Used to incorporate thio-modified bases into DNA or RNA strands for research on gene silencing, diagnostics, and therapeutic aptamers.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related biological pathways.
• Prodrug Development: Utilized in creating protected forms of active nucleoside drugs to improve stability, bioavailability, or targeting.
• Chemical Biology Probes: Acts as a building block for labeled or tagged nucleotides used to probe biological structures and functions.
• Academic & Industrial R&D: Fundamental material for method development and discovery research in medicinal and bioorganic chemistry laboratories.

Basic Information

Product Name	5-Hydroxymethyl-2',3'-o-Isopropylidene-2-Thiouridine
CAS No.	58479-71-3
Molecular Formula	C₁₃H₁₈N₂O₆S
Molecular Weight	330.36 g/mol
Synonyms	2-Thio-5-hydroxymethyl-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylidene-5-hydroxymethyl-2-thiouridine; 5-(Hydroxymethyl)-2',3'-O-(1-methylethylidene)-2-thiouridine; 2-Thiouridine, 5-(hydroxymethyl)-2',3'-O-(1-methylethylidene)-; Protected 2-Thiouridine Derivative; Isopropylidene Thiouridine Intermediate
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethyl-2',3'-o-Isopropylidene-2-Thiouridine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be aligned with customer-specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.