Description

Benzeneacetyl Chloride, A-Amino-4-Hydroxy-, (Ar)- is a specialized aromatic amino acid derivative featuring both an acid chloride and a phenolic hydroxyl group, making it a versatile chiral building block for advanced synthesis. This compound is critical for the development of complex molecules where precise stereochemistry and functional group manipulation are required. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs), peptide mimetics, and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in oncology and neurology.
• Peptide Chemistry: Used in the synthesis of non-natural amino acids and complex peptide analogs, enabling the creation of peptides with enhanced stability and biological activity.
• Asymmetric Synthesis: Serves as a crucial building block in catalytic asymmetric reactions for constructing stereogenic centers in complex organic molecules.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for metal-catalyzed reactions and organocatalysts.
• Material Science Research: Investigated for the synthesis of functionalized polymers and advanced organic materials with specific optical or electronic properties.
• Agrochemical Synthesis: Potential intermediate in the development of new, targeted agrochemicals with chiral active ingredients.

Basic Information

Product Name	Benzeneacetyl Chloride, A-Amino-4-Hydroxy-, (Ar)-
CAS No.	58433-17-3
Molecular Formula	C8H8ClNO2
Molecular Weight	185.61 g/mol
Synonyms	(R)-2-Amino-2-(4-hydroxyphenyl)acetyl chloride; D-4-Hydroxyphenylglycine acid chloride; (R)-4-Hydroxyphenylglycine acid chloride; (R)-2-Amino-2-(4-hydroxyphenyl)ethanoyl chloride; (R)-α-Amino-4-hydroxybenzeneacetyl chloride; (R)-Hpg-Cl; (R)-4-HPG acid chloride; (R)-2-(4-Hydroxyphenyl)-2-aminoacetyl chloride
EINECS	Contact for details

Quality Control

Our Benzeneacetyl Chloride, A-Amino-4-Hydroxy-, (Ar)- is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity (enantiomeric excess), chemical assay, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, strong oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (R)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.