Description

5-Mercaptouridine 5'-Diphosphate is a modified nucleotide derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and a key intermediate in the synthesis of nucleotide analogs and RNA-based therapeutics. It is primarily utilized by research institutions and biotechnology companies focused on enzymology, molecular biology, and drug discovery. The product is supplied under stringent quality control to ensure consistency and reliability for sensitive applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving RNA polymerases, kinases, and other nucleotide-processing enzymes.
• Nucleotide Analog Synthesis: Serves as a key precursor in the chemical synthesis of modified nucleoside triphosphates (NTPs) for therapeutic and diagnostic applications.
• RNA-Based Therapeutic Development: Employed in the research and development of siRNA, mRNA, and other RNA therapeutics where modified nucleotides are required to enhance stability or alter function.
• Metabolic Pathway Studies: Acts as a probe or tracer in studies investigating nucleotide salvage pathways and thiol-mediated cellular processes.
• Antiviral and Anticancer Agent Research: Investigated as a potential intermediate for the development of nucleoside analogs with antiviral or anticancer properties.
• Diagnostic Assay Development: Utilized in the formulation of specialized reagents for molecular diagnostics and high-throughput screening assays.

Basic Information

Product Name	5-Mercaptouridine 5'-Diphosphate
CAS No.	58380-73-7
Molecular Formula	C9H13N2O14P2S
Molecular Weight	482.21 g/mol
Synonyms	5-Thiouridine 5'-diphosphate; 5-SH-UDP; 5-Mercapto-UDP; 5-Thio-UDP; 5-Sulfanyluridine 5'-diphosphate; UDP-5-SH; Uridine 5'-[trihydrogen diphosphate], 5-mercapto-; 5-Mercapto-1-β-D-ribofuranosyluracil 5'-diphosphate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to a quality management system designed to meet the exacting requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.