Description

2'-Deoxy-5-Iodouridine 5'-(4-Methylbenzenesulfonate) is a chemically modified nucleoside derivative, serving as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in its role as a protected and activated precursor for the site-specific introduction of halogenated nucleosides into oligonucleotide chains. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral agents, radiopharmaceuticals, and novel oligonucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used to incorporate 5-iodo-2'-deoxyuridine residues into DNA strands for research and therapeutic applications.
• Radiopharmaceutical Precursor: Serves as a precursor for iodine-123 or iodine-131 labeled compounds used in diagnostic imaging and targeted radiotherapy.
• Biochemical Research: Employed in studies of DNA metabolism, mutagenesis, and as a substrate for thymidine kinase assays.
• Antisense & Gene Therapy Development: A valuable component in the creation of modified oligonucleotides for gene silencing and editing technologies.
• Chemical Biology Probes: Used to develop labeled probes for studying nucleic acid interactions and enzyme mechanisms.

Basic Information

Product Name	2'-Deoxy-5-Iodouridine 5'-(4-Methylbenzenesulfonate)
CAS No.	58349-27-2
Molecular Formula	C16H17IN2O8S
Molecular Weight	524.29 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 5'-Tosylate; 5-Iodo-2'-deoxyuridine 5'-(p-toluenesulfonate); 5-Iododeoxyuridine 5'-Tosylate; IUdR 5'-Tosylate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione 5'-(4-methylbenzenesulfonate); 2'-Deoxy-5-iodouridine 5'-tosylate; p-Toluenesulfonic acid 5-iodo-2'-deoxyuridine-5'-yl ester
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Iodouridine 5'-(4-Methylbenzenesulfonate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere if specified and handled in a controlled environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.