Description

2'-O-Mb-cGMP Sodium Salt is a chemically modified nucleotide analog, specifically a sodium salt derivative of cyclic guanosine monophosphate. This compound is a critical research-grade biochemical for studying intracellular signaling pathways, particularly those mediated by cyclic nucleotides. It is primarily utilized by researchers and developers in pharmaceutical R&D, molecular biology, and biochemistry for investigating enzyme kinetics, receptor binding, and as a precursor for advanced oligonucleotide synthesis.

Application

• Biochemical Research: A key tool for studying cyclic nucleotide-gated ion channels, phosphodiesterases (PDEs), and protein kinases (PKG) in signal transduction studies.
• Pharmaceutical Development: Serves as a reference standard and a potential precursor in the development of novel therapeutics targeting cardiovascular and neurological pathways.
• Enzymology Assays: Used as a substrate or inhibitor in high-throughput screening (HTS) assays to identify and characterize new drug candidates.
• Molecular Probes: Can be utilized in the synthesis of labeled probes for investigating cellular localization and activity of cGMP-dependent processes.
• Academic Research: Fundamental research in cell biology and physiology to understand the role of cGMP analogs in cellular regulation and disease models.

Basic Information

Product Name	2'-O-Mb-cGMP Sodium Salt
CAS No.	58329-72-9
Molecular Formula	C₁₆H₂₁N₅NaO₈P
Molecular Weight	489.33 g/mol
Synonyms	2'-O-Methylbenzyl-cGMP Sodium Salt; 2'-O-Mb-cyclic GMP Sodium Salt; Sodium 2'-O-(4-methylbenzyl)guanosine 3',5'-cyclic monophosphate; 2'-O-(p-Methylbenzyl)guanosine 3',5'-cyclic monophosphate sodium salt; 2'-O-MB-cGMP Na; cGMP 2'-O-methylbenzyl ether sodium salt; 2'-O-(4-Methylbenzyl)-cGMP Sodium Salt
EINECS	Contact for details

Quality Control

Our 2'-O-Mb-cGMP Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.