Description

3-o-Methyl Estradiol is a synthetic, steroidal estrogen derivative, specifically a methyl ether of estradiol. This compound is of significant interest in pharmaceutical research and development due to its modified metabolic profile and receptor binding affinity compared to the parent hormone. It serves as a critical reference standard and key intermediate for the synthesis of more complex therapeutic agents. Primary industrial users include manufacturers in the pharmaceutical, biotechnology, and advanced life science research sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and hormone therapies.
• Biochemical Research: Used as a reference compound in studies of estrogen receptor (ER) binding, selectivity, and metabolic pathways.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and assay development in analytical laboratories (HPLC, GC-MS).
• Life Science Tool: Employed in vitro and in vivo research to investigate endocrine system function and develop screening assays.
• Academic & Institutional Research: Utilized by universities and research institutes for fundamental studies in medicinal chemistry and pharmacology.

Basic Information

Product Name	3-o-Methyl Estradiol
CAS No.	57983-88-7
Molecular Formula	C19H26O2
Molecular Weight	286.41 g/mol
Synonyms	3-Methoxyestra-1,3,5(10)-trien-17β-ol; 3-Methoxy-17β-estradiol; 17β-Estradiol 3-methyl ether; 3-O-Methylestradiol; Estra-1,3,5(10)-trien-17β-ol, 3-methoxy-; 3-MeO-E2
EINECS	Contact for details

Quality Control

Our 3-o-Methyl Estradiol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.