Description

10-Keto Dextromethorphan is a key intermediate and metabolite in the synthesis and study of dextromethorphan and related compounds. This compound matters for its critical role in pharmaceutical research and development, particularly in the investigation of metabolic pathways and the creation of novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical producers focused on central nervous system (CNS) drug discovery, analytical reference standards, and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of dextromethorphan and its analogs for medicinal chemistry.
• Metabolite Reference Standard: Used in analytical laboratories for the identification and quantification of dextromethorphan metabolites in pharmacokinetic and bioanalytical studies.
• Biochemical Research: Employed in studies investigating the metabolic pathways, enzymatic transformations, and biological activity of morphinan derivatives.
• Process Development & Optimization: Serves as a key material for scaling up and refining synthetic routes in active pharmaceutical ingredient (API) manufacturing.
• Quality Control & Impurity Profiling: Acts as a known impurity or reference compound to ensure the purity and safety of dextromethorphan-based drug substances.

Basic Information

Product Name	10-Keto Dextromethorphan
CAS No.	57969-05-8
Molecular Formula	C18H25NO2
Molecular Weight	287.40 g/mol
Synonyms	10-Oxo Dextromethorphan; Dextromethorphan Ketone; (+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan-10-one; 10-Keto-DXM; 10-Oxodextromethorphan; 10-Ketodextromethorphan; Dextromethorphan-10-one
EINECS	Contact for details

Quality Control

Our 10-Keto Dextromethorphan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.