Description

3′-Deoxy-3′-Fluorouridine is a fluorinated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial building block and intermediate in the synthesis of novel antiviral and anticancer agents, leveraging its modified sugar moiety to alter biological activity. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of advanced antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and polymerase function.
• Antiviral Drug Development: Serves as a core scaffold for creating potential therapeutics targeting viral replication.
• Oncology Research: Investigated for its incorporation into oligonucleotides or as a standalone agent to study its effects on cancer cell proliferation.
• Medicinal Chemistry: A valuable building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry: Employed in scaling up the production of target active pharmaceutical ingredients (APIs) under GMP-like conditions.

Basic Information

Product Name	3′-Deoxy-3′-Fluorouridine
CAS No.	57944-13-5
Molecular Formula	C9H11FN2O5
Molecular Weight	246.20 g/mol
Synonyms	3'-Fluoro-3'-deoxyuridine; 3'-Deoxy-3'-fluorouridine; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-F-3'-dUrd; 3'-Fluorouridine; 3'-Fluoro-2'-deoxyuridine (common misnomer); 3'-F-dU; Fluorouridine derivative
EINECS	Contact for details

Quality Control

Our 3′-Deoxy-3′-Fluorouridine is produced and tested to meet the exacting standards required for research and pharmaceutical applications. Each batch undergoes rigorous analytical characterization, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all quality parameters. We support development under quality systems aligned with cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.