Description

N(6),O(2)-Dimethyladenosine is a chemically modified nucleoside derivative of adenosine, featuring methylation at the N6 and O2' positions. This specific modification is crucial for research into RNA structure, function, and the mechanisms of methyltransferases. It serves as a valuable biochemical tool and reference standard for scientists in pharmaceutical discovery and life science research. Key users include R&D laboratories and manufacturers focused on nucleoside chemistry, epigenetics, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in studies of adenosine-modifying enzymes, particularly methyltransferases.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in drug discovery pipelines involving nucleoside analogs.
• Epigenetics & Molecular Biology: A key compound for investigating RNA methylation patterns and their role in gene expression regulation and cellular processes.
• Nucleoside Chemistry Synthesis: Acts as a protected intermediate or a building block for the synthesis of more complex nucleoside derivatives and prodrugs.
• Life Science Reagents: Incorporated into specialized assay kits and research reagents for academic and industrial laboratories.

Basic Information

Product Name	N(6),O(2)-Dimethyladenosine
CAS No.	57817-83-1
Molecular Formula	C₁₂H₁₇N₅O₅
Molecular Weight	311.30 g/mol
Synonyms	2'-O-Methyl-N6-methyladenosine; N6,2'-O-Dimethyladenosine; 6-(Methylamino)-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]purine; 6-Methylamino-9-(2-O-methyl-β-D-ribofuranosyl)purine; N6-Methyl-2'-O-methyladenosine; 2'-O-Methyl-N6-methyladenosine; Adenosine, N6,2'-O-dimethyl-
EINECS	Contact for details

Quality Control

Our N(6),O(2)-Dimethyladenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.