Description

4-Fluoro-2-Nitrobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of its functional groups, enabling efficient introduction of the 4-fluoro-2-nitrobenzoyl moiety into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to synthesize active pharmaceutical ingredients (APIs), advanced intermediates, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to construct advanced intermediates for herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluoronitro aromatic system.
• Peptide Mimetics & Linker Chemistry: Employed in the preparation of peptide analogs and for constructing cleavable linkers in bioconjugation and prodrug development.
• Liquid Crystal & OLED Material Research: Serves as a building block for synthesizing fluorinated aromatic cores used in electronic and photonic materials.
• Dye & Pigment Intermediate: Utilized in the production of specialized azo dyes and high-performance pigments where fluorine substitution enhances properties.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs developing proprietary compounds for clients.

Basic Information

Product Name	4-Fluoro-2-Nitrobenzoyl Chloride
CAS No.	57750-82-0
Molecular Formula	C7H3ClFNO3
Molecular Weight	203.56 g/mol
Synonyms	2-Nitro-4-fluorobenzoyl chloride; 4-Fluoro-2-nitrobenzoic acid chloride; 4-Fluoro-2-nitrobenzoyl chloride; Benzoic acid, 4-fluoro-2-nitro-, chloride; 4-Fluoro-2-nitro-benzoyl chloride; 57750-82-0; 4-Fluoro-o-nitrobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitrobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water and alcohols; ensure containers are sealed under an inert atmosphere if necessary after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.