Description

3-Pyridinecarbonyl Chloride, 4-Methoxy- (9Ci) is a versatile and reactive heterocyclic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the 4-methoxypicolinoyl moiety. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates. Its specific reactivity profile makes it valuable for constructing molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require the picolinamide structural motif.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for metal catalysis and organocatalysts used in asymmetric synthesis.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and functional organic materials.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 4-Methoxy- (9Ci)
CAS No.	57658-52-3
Molecular Formula	C7H6ClNO2
Molecular Weight	171.58 g/mol
Synonyms	4-Methoxypicolinoyl Chloride; 4-Methoxypyridine-3-carbonyl Chloride; 4-Methoxy-3-pyridinecarbonyl Chloride; 4-Methoxynicotinoyl Chloride; 3-Carboxy-4-methoxypyridine Chloride; 4-Methoxy-3-picolinoyl Chloride; 4-Methoxypyridine-3-carboxylic Acid Chloride
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonyl Chloride, 4-Methoxy- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We employ advanced analytical techniques including HPLC, GC, and NMR for identity confirmation and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific test results is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and reactive nature, this material should be stored in a cool (15-25°C), dry place under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep the container tightly sealed in a dry environment. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0 - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.