Description

(22R)-5,6β:18,20-Diepoxy-18,22-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid 26,22-Lactone is a complex, highly functionalized ergostane-type steroidal lactone, representing a key advanced intermediate in the synthesis of bioactive natural products and pharmaceuticals. Its intricate polycyclic structure, featuring epoxide and lactone functionalities, makes it a valuable scaffold for medicinal chemistry research and the development of novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in steroid chemistry, anticancer drug discovery, and the synthesis of biologically active natural product derivatives.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of complex steroidal drugs and investigational new chemical entities.
• Medicinal Chemistry Research: Used as a precursor or model compound in structure-activity relationship (SAR) studies targeting various biological pathways.
• Anticancer Agent Development: Investigated for its potential as a lead compound or intermediate in the discovery of novel anticancer therapies due to its steroidal framework.
• Natural Product Synthesis: Employed in the total or semi-synthesis of complex natural products with ergostane skeletons.
• Biochemical Research: Utilized as a standard or probe in studies involving enzyme inhibition or receptor binding assays related to steroid metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(22R)-5,6β:18,20-Diepoxy-18,22-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid 26,22-Lactone
CAS No.	57423-73-1
Molecular Formula	C₂₈H₃₆O₇
Molecular Weight	484.58 g/mol
Synonyms	18,22-Dihydroxy-5,6:18,20-diepoxy-1-oxo-5β-ergosta-2,24-dien-26-oic acid 26,22-lactone; (22R)-5,6β:18,20-Diepoxy-18,22-dihydroxy-1-oxo-5β-ergosta-2,24-dien-26-oic acid δ-lactone; 5,6β:18,20-Diepoxy-18,22-dihydroxy-1-oxo-5β-ergosta-2,24-dien-26-oic acid 26,22-lactone; Ergosta-2,24-dien-26-oic acid derivative; Steroidal lactone epoxide
EINECS	Contact for details

Quality Control

Our (22R)-5,6β:18,20-Diepoxy-18,22-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid 26,22-Lactone is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and impurities to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere at 2-8°C to maximize stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.