Description

Tacalcitol is a synthetic vitamin D3 analog with significant biological activity. This compound is a critical active pharmaceutical ingredient (API) valued for its role in regulating cell proliferation and differentiation. It is primarily utilized by the pharmaceutical industry for the research, development, and manufacturing of topical treatments for psoriasis and other dermatological conditions.

Application

• Active Pharmaceutical Ingredient (API) in topical ointments and creams for the treatment of psoriasis vulgaris.
• Key Intermediate in the synthesis of more complex vitamin D receptor modulators.
• Research Chemical for studying the mechanisms of vitamin D metabolism and signaling pathways.
• Reference Standard in analytical laboratories for quality control and method development.
• Dermatological R&D for developing new formulations targeting hyperproliferative skin disorders.

Basic Information

Product Name	Tacalcitol
CAS No.	57333-96-7
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1α,24-Dihydroxyvitamin D3; 1α,24-(OH)₂D₃; 1α,24-Dihydroxycholecalciferol; TV-02; Curatoderm; Bonalfa; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4R)-4-hydroxy-1,5-dimethylhex-2-en-1-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our Tacalcitol is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure high purity and consistency, meeting standards suitable for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.