Description

4-(Difluoromethoxy)Benzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique difluoromethoxy group, which imparts desirable metabolic stability and lipophilicity to target molecules, making it indispensable for research and development. This compound is primarily needed by pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the difluoromethoxy moiety enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce aromatic and fluorinated segments into high-performance polymers.
• Organic Synthesis Reagent: A versatile reagent for introducing the 4-(difluoromethoxy)benzoyl moiety into complex molecules via amidation or esterification reactions.
• Material Science Research: Used in the development of organic semiconductors and other electronic materials due to its electron-withdrawing characteristics.

Basic Information

Product Name	4-(Difluoromethoxy)Benzoyl Chloride
CAS No.	57320-63-5
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	p-(Difluoromethoxy)benzoyl chloride; 4-(Difluoromethoxy)benzoic acid chloride; α,α-Difluoro-p-methoxybenzoyl chloride; Benzoyl chloride, 4-(difluoromethoxy)-; DFMBC; 57320-63-5; (4-(Difluoromethoxy)phenyl)methanoyl chloride
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Acidity (Titration)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.