Description

Bis(4-Nitrobenzyl) Phosphorochloridate is a specialized organophosphorus compound primarily used as a key phosphorylating and coupling agent in advanced chemical synthesis. Its value lies in its ability to introduce the phosphorochloridate moiety under controlled conditions, enabling the construction of complex molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and nucleotide analogs.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of nucleotide prodrugs and phosphate ester-based active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides and insecticides that contain organophosphate functional groups.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Peptide & Oligonucleotide Chemistry: Employed as a phosphorylating agent in the solid-phase synthesis of modified oligonucleotides and phosphopeptides.
• Polymer Modification: Can be used to introduce phosphate groups into polymer backbones for specialty material applications.
• Ligand Synthesis for Catalysis: Useful in preparing phosphonate and phosphate-based ligands for metal catalysis.

Basic Information

Product Name	Bis(4-Nitrobenzyl) Phosphorochloridate
CAS No.	57188-46-2
Molecular Formula	C14H12ClNO6P
Molecular Weight	356.68 g/mol
Synonyms	Phosphorochloridic Acid, Bis(4-Nitrobenzyl) Ester; Bis(p-Nitrobenzyl) Chlorophosphate; 4-Nitrobenzyl Phosphorodichloridate (dimer form); PNBCP; BNBP-Cl; (4-Nitrobenzyl) Phosphorochloridate Dimer; Chlorobis(4-nitrobenzyl) Phosphate; O,O-Bis(4-nitrobenzyl) Phosphorochloridate
EINECS	Contact for details

Quality Control

Every batch of Bis(4-Nitrobenzyl) Phosphorochloridate is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	Conforms
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.