Description

p-Azidophenacyl Bromide-1-14C is a carbon-14 radiolabeled derivative of p-azidophenacyl bromide, a versatile photoaffinity labeling reagent. This compound is specifically designed for advanced research applications where precise tracking and covalent binding studies are required. It is an essential tool for scientists in pharmaceutical R&D, biochemistry, and chemical biology who are investigating protein-ligand interactions, metabolic pathways, and reaction mechanisms.

Application

• Photoaffinity Labeling Studies: Used as a critical reagent to covalently cross-link and identify biological targets, such as proteins and receptors, upon UV irradiation.
• Radiolabeled Tracer Synthesis: Serves as a key intermediate for synthesizing carbon-14 labeled compounds for use in absorption, distribution, metabolism, and excretion (ADME) studies.
• Mechanistic Biochemistry Research: Enables detailed investigation of enzyme active sites and binding pockets through irreversible photo-cross-linking.
• Proteomics and Chemical Proteomics: Facilitates the discovery and validation of drug targets by tagging and enriching specific biomolecules.
• Material Science Functionalization: Applied in surface modification and polymer chemistry to introduce photoreactive azide groups for subsequent "click" chemistry reactions.

Basic Information

Item	Detail
Product Name	p-Azidophenacyl Bromide-1-14C
CAS No.	57122-94-8
Molecular Formula	C8H614CN3OBr
Molecular Weight	Contact for details
Synonyms	4-Azidophenacyl Bromide-1-14C; 2-Bromo-1-(4-azidophenyl)ethanone-1-14C; α-Bromo-4-azidoacetophenone-1-14C; p-Azidophenacyl Bromide (14C Labeled); Photoaffinity Labeling Reagent-1-14C; 14C-pAPB; 1-(4-Azidophenyl)-2-bromoethanone-1-14C; Bromo(4-azidophenyl)methanone-1-14C
EINECS	Contact for details

Quality Control

Every batch of p-Azidophenacyl Bromide-1-14C is manufactured and analyzed under strict quality control protocols to ensure high chemical and radiochemical purity, essential for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, purity by HPLC, and radiochemical purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold storage conditions (e.g., -20°C or as specified on the label) to maintain stability and specific activity. Keep away from heat and incompatible materials. Handle and store in accordance with all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	Yellow to orange crystalline solid or solution
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Chemical)
Radiochemical Purity	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent (if supplied as solution)	Specified on label (e.g., Acetonitrile, Toluene)
Concentration	Specified on label

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.