Description

1-Naphthalenecarbonyl Chloride,4-Fluoro- is a high-purity fluorinated aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce both the naphthoyl and reactive acyl chloride functionalities into target molecules, enabling the creation of complex chemical architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-quality intermediate for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated aromatic cores in electronic materials, improving charge transport and thermal stability.
• Polymer Modification: Employed to introduce naphthalene units and fluorinated segments into polymer backbones, enhancing material properties like refractive index and chemical resistance.
• Dye & Pigment Manufacturing: Intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct biaryl systems.
• Peptide Mimetics & Conjugation: Useful for acylating amines in peptide chains or for creating fluorescent probes and bioconjugates via amide bond formation.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and discovering novel chemical entities.

Basic Information

Product Name	1-Naphthalenecarbonyl Chloride,4-Fluoro-
CAS No.	56886-72-7
Molecular Formula	C11H6ClFO
Molecular Weight	208.62 g/mol
Synonyms	4-Fluoro-1-naphthoyl chloride; 4-Fluoronaphthalene-1-carbonyl chloride; 1-Naphthoyl chloride, 4-fluoro-; 4-Fluoro-1-naphthalenecarbonyl chloride; 4-Fluoronaphthoyl chloride; 1-Carbonyl chloride-4-fluoronaphthalene; 4-Fluoro-1-naphthoic acid chloride
EINECS	Contact for details

Quality Control

Our 1-Naphthalenecarbonyl Chloride,4-Fluoro- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from techniques including HPLC, GC, NMR, and IR spectroscopy. Our commitment is to supply material that meets the stringent requirements for pharmaceutical and advanced material synthesis, supporting your regulatory and process validation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and separated from incompatible materials such as bases, amines, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.