Description

1-(Trichloroacetyl)-1H-Imidazole is a versatile and highly reactive chemical building block, primarily used as an acylating and activating agent in organic synthesis. Its core value lies in its ability to efficiently introduce the trichloroacetyl group or activate carboxylic acids for subsequent amide bond formation, enabling the synthesis of complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing heterocyclic compounds and amide derivatives.
• Peptide Synthesis: Acts as a coupling agent or protecting group activator in solid-phase and solution-phase peptide chemistry.
• Agrochemical Production: Used in the manufacture of herbicides, fungicides, and other crop protection agents that contain imidazole or trichloromethyl motifs.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating specialty polymers with specific thermal or chemical resistance properties.
• Chemical Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.
• Dye and Pigment Synthesis: Intermediate in the production of complex organic dyes and colorants.

Basic Information

Product Name	1-(Trichloroacetyl)-1H-Imidazole
CAS No.	56739-51-6
Molecular Formula	C5H3Cl3N2O
Molecular Weight	213.45 g/mol
Synonyms	1H-Imidazole, 1-(trichloroacetyl)-; Trichloroacetyl Imidazole; N-Trichloroacetyl Imidazole; 1-(Trichloroacetyl)imidazole; Imidazole, 1-(trichloroacetyl)-; 1-(2,2,2-Trichloroacetyl)imidazole; 1-(Trichloroacetyl)-1H-imidazole; 1-Trichloroacetyl-1H-imidazole
EINECS	Contact for details

Quality Control

Our 1-(Trichloroacetyl)-1H-Imidazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.