Description

3-Deaza-6-Azauridine is a synthetic nucleoside analog, a modified uridine derivative where both the nitrogen at the 3-position and the carbon at the 6-position of the uracil ring have been replaced. This compound is of significant interest in biochemical and pharmaceutical research due to its unique structure, which allows it to act as a potent inhibitor of specific enzymes involved in nucleotide metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral and anticancer drug discovery, as well as in fundamental studies of nucleic acid chemistry and enzymology. The compound serves as a critical tool for investigating cellular processes and developing novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate analog to study the mechanisms and inhibition of enzymes like cytidine deaminase and thymidylate synthase.
• Antiviral Drug Development: Investigated for its potential to interfere with viral replication by mimicking natural nucleosides.
• Anticancer Research: Explored for its ability to disrupt DNA synthesis and induce apoptosis in rapidly dividing cancer cells.
• Nucleic Acid Chemistry: Serves as a building block or probe in the synthesis and study of modified oligonucleotides.
• Enzyme Kinetics Studies: Employed to determine kinetic parameters and inhibition constants (Ki) for target enzymes.
• Pharmacology & Toxicology: Used in in vitro and cellular assays to evaluate metabolic pathways and cellular responses.

Basic Information

Product Name	3-Deaza-6-Azauridine
CAS No.	56707-91-6
Molecular Formula	C9H12N2O6
Molecular Weight	244.20 g/mol
Synonyms	6-Aza-3-deazauridine; 3-Deaza-6-azauridine; 1-β-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione; 1-(β-D-Ribofuranosyl)-as-triazine-3,5(2H,4H)-dione; NSC 126303; 3-Deaza-6-aza-Urd
EINECS	Contact for details

Quality Control

Our 3-Deaza-6-Azauridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to meet the stringent requirements of research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.