Description

5-Fluoro-4'-Thiouridine is a chemically modified nucleoside analog, a critical building block in advanced pharmaceutical and biochemical research. Its unique structure, incorporating both fluorine and a thioether group, makes it a valuable precursor for the synthesis of novel antiviral and anticancer agents, particularly in the development of modified oligonucleotides. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, high-quality raw materials for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used as a modified building block in oligonucleotide synthesis for studying RNA structure, function, and inhibition.
• Antiviral Drug Development: Serves as a core scaffold for creating analogs that target viral polymerases and replication mechanisms.
• Proteomics & Genomics: Employed in the development of probes and tools for nucleic acid labeling and detection.
• Medicinal Chemistry: A versatile starting material for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Diagnostic Reagent Synthesis: Used in the manufacture of specialized components for diagnostic assays and kits.

Basic Information

Product Name	5-Fluoro-4'-Thiouridine
CAS No.	56527-42-5
Molecular Formula	C9H11FN2O5S
Molecular Weight	278.26 g/mol
Synonyms	4'-Thio-5-fluorouridine; 5-Fluoro-4'-thiouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Flu-4'-S-Urd; 5-F-4'-thioU; 4'-Thio-5-FUrd
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4'-Thiouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.