Description

1H-Imidazole-5-Carbonyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the imidazole-5-carbonyl moiety, a key structural feature in numerous bioactive molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders and metabolic diseases.
• Agrochemical Synthesis: Building block for creating novel fungicides, herbicides, and plant growth regulators with enhanced efficacy.
• Peptide & Protein Modification: Used for the selective acylation of amino groups in peptides and proteins for biochemical research and bioconjugation.
• Material Science: Monomer or cross-linking agent in the development of specialty polymers, coatings, and functional materials.
• Ligand & Catalyst Development: Synthesis of complex ligands for metal-organic frameworks (MOFs) and homogeneous catalysis.
• Custom Synthesis & R&D: Fundamental reagent for medicinal chemistry and process development in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	1H-Imidazole-5-Carbonyl Chloride
CAS No.	56460-32-3
Molecular Formula	C4H3ClN2O
Molecular Weight	130.53 g/mol
Synonyms	Imidazole-5-carbonyl chloride; 5-Imidazolecarbonyl chloride; 1H-Imidazole-5-carboxylic acid chloride; Imidazole-5-carboxylic acid chloride; 5-Carboxyimidazole chloride; 1H-Imidazole-5-carbonyl chloride; Imidazole-5-COCl
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-5-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.