Description

2-Benzyloxyethyl Chloroformate is a versatile and reactive chloroformate ester used as a key building block in organic synthesis. Its primary value lies in its role as a protective group reagent and coupling agent, facilitating the controlled formation of amides, esters, and carbamates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing carbamate or carbonate protecting groups.
• Peptide Synthesis: Used as a coupling agent or for the temporary protection of amino groups during solid-phase and solution-phase peptide synthesis.
• Agrochemical Manufacturing: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialized polycarbonates and polyurethanes.
• Bioconjugation: Facilitates the covalent attachment of small molecules, dyes, or polymers to biomolecules like proteins and antibodies for diagnostic and therapeutic applications.
• Material Science Research: Employed in surface functionalization and the development of advanced organic materials with tailored properties.

Basic Information

Product Name	2-Benzyloxyethyl Chloroformate
CAS No.	56456-19-0
Molecular Formula	C10H11ClO3
Molecular Weight	214.65 g/mol
Synonyms	2-(Benzyloxy)ethyl chloroformate; Benzyl 2-hydroxyethyl carbonate chloroformate; Ethanol, 2-(phenylmethoxy)-, 1-chloroformate; Carbonochloridic acid, 2-(phenylmethoxy)ethyl ester; 2-(Benzyloxy)ethanol chloroformate; O2-Benzyl glycol chloroformate; (2-Benzyloxyethoxy)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Benzyloxyethyl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity and identity confirmation (IR, NMR). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.