Description

[1-(Isopropylideneamino)-2-[4-(Trimethylsiloxy)Phenyl]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a sophisticated organosilicon-protected phosphonic acid derivative, serving as a critical synthetic intermediate and protecting group reagent. Its value lies in its dual functionality, offering a masked phosphonic acid moiety and a silyl-protected phenol, which is essential for complex, multi-step organic syntheses under anhydrous conditions. This compound is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing bioactive molecules and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate bioisosteres.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, plant growth regulators, and fungicides with phosphonate activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Surface Modification Agent: Employed to functionalize silica, glass, or metal oxide surfaces with organic phosphonate layers for improved adhesion, corrosion resistance, or biocompatibility.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers, including flame retardants and dental materials.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups protect sensitive hydroxyl and phosphonic acid functionalities during complex synthetic sequences, allowing for selective deprotection later.

Basic Information

Product Name	[1-(Isopropylideneamino)-2-[4-(Trimethylsiloxy)Phenyl]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56227-26-0
Molecular Formula	C₂₁H₄₂NO₄PSi₃
Molecular Weight	503.78 g/mol
Synonyms	Phosphonic acid, [1-[(1-methylethylidene)amino]-2-[4-[(trimethylsilyl)oxy]phenyl]ethyl]-, bis(trimethylsilyl) ester; [1-(Isopropylideneamino)-2-(4-trimethylsiloxyphenyl)ethyl]phosphonic Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) [1-(isopropylideneamino)-2-[4-(trimethylsiloxy)phenyl]ethyl]phosphonate; TMS-Protected Phosphonate Ester; N-(1-Diethoxyphosphoryl-2-(4-trimethylsiloxyphenyl)ethyl)acetone imine bis(trimethylsilyl) ester (related structure).
EINECS	Contact for details

Quality Control

Our [1-(Isopropylideneamino)-2-[4-(Trimethylsiloxy)Phenyl]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ³¹P), HPLC, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture ingress and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.