Description

4-[Bis(Trimethylsiloxy)Phosphinyl]-2-[(Trimethylsilyl)Amino]Butanoic Acid Trimethylsilyl Ester is a highly functionalized organosilicon compound featuring multiple silyl protecting groups, making it a valuable intermediate in advanced synthetic chemistry. Its primary value lies in its role as a key building block for the synthesis of complex molecules, particularly in pharmaceutical research and specialty chemical manufacturing. This compound is essential for R&D chemists and process development scientists working in peptide mimetics, prodrug development, and organophosphorus chemistry, where its unique structure facilitates challenging synthetic transformations.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing phosphorus or modified amino acid motifs.
• Peptide & Peptidomimetic Synthesis: Used to introduce protected phosphonate or phosphinyl groups into peptide chains, enabling the creation of protease-resistant analogs and bioactive compounds.
• Prodrug Development: Serves as a versatile scaffold for designing prodrugs, where the silyl ester and amino groups can be strategically modified for targeted drug delivery and controlled release.
• Organophosphorus Chemistry Research: A valuable reagent for exploring new reactions and methodologies in phosphorus chemistry due to its bis(trimethylsiloxy)phosphinyl moiety.
• Specialty Chemical Manufacturing: Employed in the production of high-value, custom fine chemicals for agrochemical, material science, and catalyst development applications.
• Silicon-Based Protecting Group Strategy: Utilized in multi-step syntheses where robust protection of carboxylic acid and amino functionalities is required under specific reaction conditions.

Basic Information

Product Name	4-[Bis(Trimethylsiloxy)Phosphinyl]-2-[(Trimethylsilyl)Amino]Butanoic Acid Trimethylsilyl Ester
CAS No.	56196-75-9
Molecular Formula	C16H42NO6PSi4
Molecular Weight	512.93 g/mol
Synonyms	2-[(Trimethylsilyl)amino]-4-[bis(trimethylsiloxy)phosphinyl]butanoic acid trimethylsilyl ester; Butanoic acid, 4-[bis(trimethylsiloxy)phosphinyl]-2-[(trimethylsilyl)amino]-, trimethylsilyl ester; 4-[Bis(trimethylsiloxy)phosphinyl]-2-[(trimethylsilyl)amino]butanoic acid TMS ester; Phosphinyl-protected amino acid silyl ester; TMS-ester of 4-(bis-TMS-oxy-phosphinyl)-2-(TMS-amino)butanoic acid
EINECS	Contact for details

Quality Control

Our production of 4-[Bis(Trimethylsiloxy)Phosphinyl]-2-[(Trimethylsilyl)Amino]Butanoic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ³¹P), HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a cGMP-compliant quality management system to support its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.